Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
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چکیده
منابع مشابه
Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia.
Chromosomal translocations involving the MLL gene occur in about 80% of infant leukemia. In the search for possible agents inducing infant leukemia, we identified bioflavonoids, natural substances in food as well as in dietary supplements, that cause site-specific DNA cleavage in the MLL breakpoint cluster region (BCR) in vivo. The MLL BCR DNA cleavage was shown in primary progenitor hematopoie...
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Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied ...
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I leukemia, diagnosed in the first 12 months of life, is extremely rare in the United States; the overall annual incidence is estimated to be approximately 37 cases per million infants (1). Certain demographic information with respect to incidence may provide important clues regarding etiology. White infants experience about a 50% higher risk than black infants, and females about a 50% higher r...
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Infant acute leukemia (IAL) frequently involves breakage and recombination of the MLL gene with one of several potential partner genes. These gene fusions arise in utero and are similar to those found in leukemias secondary to chemotherapy with inhibitors of topoisomerase II (topo-II). This has led to the hypothesis that in utero exposures to chemicals may cause IAL via an effect on topo-II. We...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.070061297